Michigan State at Ohio State odds, picks and prediction

The No. 25 Michigan State Spartans (19-10, 10-8 Big Ten) and No. 23 Ohio State Buckeyes (18-9, 11-7) tangle Thursday in a Top-25 conference showdown in Columbus, Ohio. The battle at Schottenstein Center is set for a 7 p.m. ET start time. Below, we look at the Michigan State vs. Ohio State odds and lines, and make our expert college basketball picks, predictions and bets.

Michigan State fell at Michigan 87-70 Tuesday and has stumbled its way to a 2-6 mark since Feb. 5. MSU has struggled defensively over that stretch, allowing 74.3 points per game.

The Spartans and Buckeyes are meeting for the first time since Feb. 25, 2021. Michigan State won that matchup 71-67 at home and is 5-1 over its last six versus OSU.

The Buckeyes are coming off a sluggish 78-70 home loss as 14.5-point favorites to Nebraska Tuesday. Ohio State struggled from the floor for a second straight game – both were losses for OSU, which had won four of its previous five games. The Buckeyes rank as one of the better 3-point-shooting teams in the Big Ten at 36.9%, but they have shot just 27.8% from beyond the arc over their last three home games.

Rankings courtesy of the Ferris Mowers Coaches Poll powered by USA TODAY Sports.

Michigan State at Ohio State odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:12 a.m. ET.

  • Money line: Michigan State +220 (bet $100 to win $220) | Ohio State -280 (bet $280 to win $100)
  • Against the spread (ATS): Michigan State +5.5 (-105) | Ohio State -5.5 (-120)
  • Over/Under (O/U): 138.5 (O: -110 | U: -110)

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Michigan State at Ohio State odds, lines, picks and predictions


Ohio State 71, Michigan State 64

Money line


Ohio State (-280) would cost nearly three times your potential return. That’s not wise sports betting.

Against the spread

On the road, MSU has lost five in a row ATS.

OSU is 4-1 ATS over its last five against winning teams.

Look for a bounce-back shooting performance for the Buckeyes. Their free-throw frequency has been on the rise, and they figure to benefit in the turnover exchange.

BET OHIO STATE -5.5 (-120).


The OSU defense has logged solid defensive performances after losses. In games following a loss, the Buckeyes are 4-1 straight up in their last five.

Ohio State has played at markedly slower pace numbers of late. MSU has scored more than 65 points just once in its last six efforts on the road.

BACK THE UNDER 138.5 (-110).

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