Duke at Pittsburgh odds, picks and prediction

The No. 2 Duke Blue Devils (25-4, 15-3 ACC) and Pittsburgh Panthers (11-18, 6-12) tangle 8 p.m. ET Tuesday at Petersen Events Center in Pittsburgh. Below, we look at the Duke vs. Pittsburgh odds and lines, and make our expert college basketball picks, predictions and bets.

Duke has lost just once (Feb. 7 vs. Virginia) since falling at Florida State in overtime Jan. 18. The Blue Devils are 11-1 overall and 7-0 on the road over that stretch.

DU is coming off a 97-point performance at Syracuse Saturday where three starters scored 20 or more points for the highest-scoring team in the ACC (80.1 points per game).

The Panthers rank last in the circuit in scoring (62.5 PPG) and have not played since losing 85-64 to Miami (Fla.) last Tuesday. They are 3-6 since Jan. 30.

Pittsburgh snapped a five-game losing skid against Duke the last time these programs met. On Jan. 19, 2021, in Pittsburgh, Pa., Pitt downed Duke 79-73. The Panthers outscored the Devils 24-11 at the free-throw that day.

Rankings courtesy of the Ferris Mowers Coaches Poll powered by USA TODAY Sports.

Duke at Pittsburgh odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:09 p.m. ET.

  • Money line: Duke -1400 (bet $1,400 to win $100) | Pittsburgh +750 (bet $100 to win $750)
  • Against the spread (ATS): Duke -14.5 (-112) | Pittsburgh +14.5 (-108)
  • Over/Under (O/U): 137.5 (O: -115 | U: -107)

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Duke at Pittsburgh odds, lines, picks and predictions


Duke 75, Pittsburgh 64

Money line


Against the spread

The Panthers are 4-0 ATS in their last four games following a straight-up loss of more than 20 points, and they’re in a likable spot here.

With Duke playing its third straight game away from Cameron Indoor Stadium, peg this contest against mercurial Pitt as having enough of a chance for landing somewhere in the Devils by 10-or-12 range.

TAKE PITTSBURGH +14.5 (-108).


Three out of the last four Pitt home games have hit the Over. Duke has been a solid Over play the last few weeks, and Over tickets have cashed in six of its last eight.

BACK THE OVER 137.5 (-115) on a strong lean.

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