Atletico Madrid vs. Manchester United odds, expert picks and prediction

Manchester United visits the Estadio Wanda Metropolitano to take on Atletico Madrid Wednesday in the UEFA Champions League Round of 16 at 3 p.m. ET. Below, we preview the Atletico Madrid vs. Manchester United odds and lines, and make our best Champions League bets, picks and predictions.

Man U is coming off a thrilling 4-2 win over Leeds United in EPL action. It has won two straight league games, both by 2 goals. Man U is in fourth place in the EPL.

Man U finished first in Group H, scoring 11 goals and allowing 8 in six group-stage matches. Atletico went 2-3 with a draw in Group B, which was dominated by Liverpool.

Atletico managed a second-place finish in its group, scoring 7 goals and giving up 8, just 3 to non-Liverpool clubs. Atletico sit fifth in La Liga play.

Atletico Madrid vs. Manchester United: Odds, picks and predictions

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:51 a.m. ET.

  • Money line: Atletico Madrid +165 (bet $100 to win $165) | Manchester United +185 (bet $100 to win $185) | Draw +210
  • Over/Under: 2.5 (O: +115 | U: -145)

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Atletico Madrid 1, Manchester United 1

Money line (ML)

LEAN to the DRAW (+210).

Man U is on the road coming off a tedious match this past weekend. While phenom F Cristiano Ronaldo is expected to start, F Mason Greenwood isn’t expected to play and F Edinson Cavani is listed as doubtful, per

Atletico M Koke is also listed as doubtful as is 26-year-old M Thomas Lemar. Atletico is at home, where it is 7-2-3. However, it has just three wins in its last seven matches.

Man U has been playing at a higher level, but on the road, I wouldn’t fully back it to win outright. The DRAW (+210) is the best way to play the money line, but it’s not my best bet in this Round of 16 battle.

Over/Under (O/U)


I don’t have a good gauge on the projected goals, and given both teams’ ability to score, yet subsequent ability to limit goals, I’d prefer a bet on BOTH TEAMS TO SCORE (-122).

Atletico Madrid has scored 45 goals in 25 La Liga matches. It scored 8 goals in six matches, including a 2-goal performance against Liverpool, which has allowed the fourth-fewest goals in the EPL.

Man U has 44 goals in 26 EPL matches. It scored 11 goals in six group-stage performances, scoring at least 1 goal in every match.

Combine it all, and it seems likely both dynamic offenses find the back of the net at least once.

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