St. Louis Cardinals at San Diego Padres odds, picks and prediction

May 14, 2021; San Diego, California, USA; St. Louis Cardinals third baseman Nolan Arenado (R) gestures after hitting a home run against the San Diego Padres during the ninth inning at Petco Park. Mandatory Credit: Orlando Ramirez-USA TODAY Sports

The St. Louis Cardinals (23-16) and San Diego Padres (22-17) play Game 2 of a three-game series Saturday at Petco Park. First pitch is scheduled for 8:40 p.m. ET (on FS1). Let’s analyze BetMGM Sportsbook‘s lines around the Cardinals vs. Padres odds with MLB picks and predictions.

Season series: Padres lead 1-0

Despite being without SS Fernando Tatis Jr., RF Wil Myers, 1B Eric Hosmer and utility players Jurickson Profar and Jorge Mateo due to COVID-19 issues, the Padres won Friday’s series opener 5-4.

RHP Adam Wainwright is projected to start for St. Louis. The 16-year veteran is 2-3 with a 3.80 ERA (42 2/3 IP, 18 ER), 1.22 WHIP, 8.9 K/9 and 2.5 BB/9 in 7 starts this season.

  • Last outing: Win, 8 1/3 IP, 0 ER, 3 H, 3 BB, 5 K in the Cardinals’ 2-0 home shutout of the Colorado Rockies Sunday.
  • Career vs. Padres (regular season): 7-4, 2.19 ERA (82 1/3 IP, 20 ER), 1.13 WHIP, 9.0 K/9 in 12 starts and 3 relief appearances.

RHP Chris Paddack is the Padres’ projected starter. He is 1-3 with a 4.78 ERA (26 1/3 IP, 14 ER), 1.41 WHIP, 8.9 K/9 and 2.7 BB/9 through 6 starts.

  • Last outing: No-decision, 3 IP (due to a pitch-count limit after coming off the injured list), 0 ER, 4 H, 1 BB, 4 K at the San Francisco Giants Sunday – Padres won 11-1.
  • Career vs. Cardinals (regular season): 1-0, 0.93 ERA (9 2/3 IP, 1 ER), 3 H, 5 BB, 12 K in 2 starts in 2019.

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Cardinals at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 9:35 a.m. ET.

  • Money line: Cardinals +110 (bet $100 to win $110) | Padres -135 (bet $135 to win $100)
  • Against the spread/ATS: Cardinals +1.5 (-190) | Padres -1.5 (+155)
  • Over/Under: 7 (O: -110 | U: -110)


Cardinals 4, Padres 2

Money line (ML)

ST. LOUIS (+110) is the STRONGEST PLAY – 1½ times your usual wager. Wainwright was spectacular in his last start, just missing a complete-game shutout by two outs.

Don’t let his 2021 road stats (0-1, 6.52 ERA, 9 2/3 IP, 7 ER) scare you away. They’re inflated due to a rough outing at the Cincinnati Reds (2 2/3 IP, 6 ER) in his season debut. He held the Washington Nationals to 1 earned run and struck out a season-high 10 batters over 7 innings in his other road start.

Sure, the Padres won Friday, but the odds are against them with Tatis, Myers and Hosmer out.

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Run line/Against the spread (ATS)

PASS. The Cardinals are tied with the San Francisco Giants for the majors’ best ATS record, but the -190 juice on St. Louis +1.5 is too high for my liking.

ATS records: Cardinals 25-14 | Padres 20-19

Over/Under (O/U)

UNDER 7 (-105) is worth a HALF-UNIT wager. The Under is 5-1 in Wainwright’s last six starts, and both clubs feature decent bullpens. San Diego relievers are first in the NL with a 2.73 ERA, while the Cardinals are sixth at 3.71.

O/U records: Cardinals 17-18-3 | Padres 17-22

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2021 MLB 39-41-2 10-13-1 -6.87
2020 MLB 80-59-1 39-21 +24.79
2021 (all sports) 142-126-3 59-54-1 +6.68
*SP: Strongest plays; ROI: Return on investment

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