Detroit Pistons at Philadelphia 76ers odds, picks and prediction

May 7, 2021; Philadelphia, Pennsylvania, USA; Philadelphia 76ers center Joel Embiid (21) and forward Tobias Harris (12) react after forcing a jump ball in the closing seconds of the fourth quarter against the New Orleans Pelicans at Wells Fargo Center. Mandatory Credit: Bill Streicher-USA TODAY Sports

The Detroit Pistons (20-47) travel to meet the Philadelphia 76ers (46-21) Saturday at Wells Fargo Center. Tip-off is set for 7 p.m. ET. Below, we analyze the Pistons vs. 76ers odds and lines, with NBA picks and predictions.

The Pistons picked up an impressive 111-97 win over the Memphis Grizzlies on Thursday, winning outright as a nine-point underdog as the Under connected. The win snapped a four-game losing streak, while the Under is 6-2 across the past eight outings.

The 76ers posted a 109-107 win over the New Orleans Pelicans, not even coming close to covering an 11.5-point number. It was still good for their seventh consecutive victory while going 5-2 ATS during the span.

Pistons at 76ers: Odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 8:20 a.m. ET.

  • Money line: Pistons +450 (bet $100 to win $450) | 76ers -650 (bet $650 to win $100)
  • Against the spread/ATS: Pistons +11 (-115) | 76ers -11 (-105)
  • Over/Under: 221.5 (O: -110 | U: -110)

Pistons at 76ers: Key injuries


  • PG Hamidou Diallo (personal) out
  • SG Wayne Ellington (calf) questionable
  • SF Jerami Grant (knee) questionable
  • PG Killian Hayes (illness) questionable
  • PG Cory Joseph (ankle) questionable
  • SF Josh Jackson (mouth) out
  • SG Rodney McGruder (elbow) out
  • PG Dennis Smith Jr. (knee) out


  • SG Furkan Korkmaz (ankle) questionable

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Pistons at 76ers: Odds, lines, predictions and picks


76ers 112, Pistons 107

Money line (ML)

The 76ers (-650) will cost you six and a half times your potential return, and that’s way too risky. They barely edged the Pelicans on Friday, and now they have the quick turnaround against a team coming off a big win.


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Against the spread (ATS)

The PISTONS +11 (-115) have a lengthy injury report, but that didn’t stop them from dealing the Grizzlies a loss last time out as an underdog.

The 76ers -11 (-105) barely made it past the Pels on Friday. While I expect the Sixers to get it done, take the Pistons with the points. They will keep it within single digits.

Over/Under (O/U)

UNDER 221.5 (-110) is the lean here. The Under is 9-3-1 in Detroit’s last 13 games overall while going 4-1 in the past five road outings.

The Under is also the trend for Philly, going 5-1 in the past six as a home favorite, and 14-5 in the past 19 overall as a favorite. In addition, the Under is 6-1 in the past seven when playing on no rest.

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