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Pittsburgh Pirates at San Diego Padres odds, picks and prediction

Apr 24, 2021; Los Angeles, California, USA; San Diego Padres right fielder Wil Myers (5) scores past Los Angeles Dodgers catcher Will Smith (16) on a single by San Diego Padres left fielder Jurickson Profar (10) in the second inning of the game at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-USA TODAY Sports

The Pittsburgh Pirates (12-16) and San Diego Padres (17-13) play the second game of a three-game set Tuesday at Petco Park with a 10:10 p.m. ET first pitch. Let’s analyze BetMGM Sportsbook‘s lines around the Pirates vs. Padres odds with MLB picks and predictions.

RHP Mitch Keller is the projected starting pitcher for the Pirates. He is 1-3 with an 8.20 ERA, 1.98 WHIP, 9.2 K/9 and 6.3 BB/9 over 18 2/3 IP through five starts.

Keller was smacked around by the Padres in his first meeting with them April 15. He allowed 7 earned runs on 9 hits and 3 walks in just 3 1/3 innings in a loss in the Steel City.

LHP Ryan Weathers is the projected starting pitcher for the Padres. He is 1-0 with a 0.55 ERA, 0.61 WHIP, 8.8 K/9 and 3.3 BB/9 over 16 1/3 IP through 3 starts and 3 relief appearances.

Weathers allowed just 1 hit and 1 walk with 6 strikeouts over 5 2/3 scoreless innings in a no-decision in his second-to-last start April 22 against the Los Angeles Dodgers.

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Pirates at Padres odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 1:20 p.m. ET.

  • Money line: Pirates +200 (bet $100 to win $200) | Padres -225 (bet $225 to win $100)
  • Against the spread/ATS: Pirates +1.5 (-125) | Padres -1.5 (+105)
  • Over/Under: 8 (Over -105 | Under -115)

Prediction

Padres 8, Pirates 2

Money line (ML)

The PADRES (-225) are the slam-dunk play behind the prospect Weathers, who has been fairly effective against top-notch foes.

It will be interesting to see if he brings the same intensity against the lowly Pirates. Pittsburgh will be overmatched with the struggling Keller on the bump.

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Run line/Against the spread (ATS)

The PADRES -1.5 (+105) are worth a roll of the dice laying the run and a half. They struggled on offense Monday, but they snuck out a 2-0 win and covered the run line.

The San Diego offense should provide a lot more runs Tuesday.

Over/Under (O/U)

The OVER 8 (-105) is the play, and the Padres have the opportunity to take care of the Over on their own with the erratic Keller starting.

Despite Monday’s result, the Over is still 7-3-1 in the past 11 head-to-head meetings, including 4-1 in the previous five at Petco.

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