San Diego Padres at Arizona Diamondbacks odds, picks and prediction

Apr 25, 2021; Los Angeles, California, USA; San Diego Padres shortstop Fernando Tatis Jr. (23) celebrates after defeating the Los Angeles Dodgers 8-7 at Dodger Stadium. Mandatory Credit: Kelvin Kuo-USA TODAY Sports

The San Diego Padres (13-12) and Arizona Diamondbacks (12-11) square off in the second game of a three-game series Wednesday at 9:40 p.m. ET at Chase Field. Let’s analyze BetMGM Sportsbook‘s lines around the Padres vs. Diamondbacks odds with MLB picks and predictions.

LHP Ryan Weathers is the projected starting pitcher for the Padres. In five appearances this season (two starts) he is 1-0 with a 0.59 ERA, 0.59 WHIP, 9.4 K/9 and 2.9 BB/9 in 15 1/3 IP.

Weathers hurled three scoreless innings against Arizona with only one hit given up earlier this month in his big league debut.

Both of his starts came against a potent Dodger offense, and he totaled 9 1/3 IP with two hits allowed, 0 ER, and nine strikeouts while reaching 89 pitches last time out.

RHP Taylor Widener is set to make his fifth start of the season for Arizona. In his first four outings, he has gone 1-0 with a 2.82 ERA, 1.12 WHIP, 7.3 K/9 and 2.4 BB/9 in 22 1/3 IP.

Widener struck out seven batters in his last start, which was against the Reds but also served up three homers.

Overall, his surface stats haven’t been supported by his skills, and he has succeeded in large part due to a .234 BABIP and 88.2% left on-base percentage.

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Padres at Diamondbacks odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 9:17 a.m. ET.

  • Money line: Padres -175 (bet $175 to win $100) | Diamondbacks +145 (bet $100 to win $145)
  • Against the spread/ATS: Padres -1.5 (-110) | Diamondbacks +1.5 (-110)
  • Over/Under: 9 (O: -115 | U: -105)


Padres 7, Diamondbacks 4

Money line (ML)

Arizona has been on a roll lately, winning seven of their last eight games and averaging 6.6 runs per game during that span.

But, the Padres can score some runs, too, and the early season success for Weathers looks far more legit than that of Widener.

Backing the PADRES (-175) is the play here.

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Run line/Against the spread (ATS)

The Padres have won 13 games this season, and 10 have been decided by more than one run, including six of their eight road victories.

A big day against Widener would not be surprising, and even if it’s tied late, the road team has a chance to put up a big inning.

Look for the PADRES -1.5 (-110) to win this contest by more than one run.

Over/Under (O/U)

The Diamondback offense is hot, and the Padres are facing a pitcher due for some major regression. The Over is 7-2 in Arizona’s last nine home games, and OVER 9 (-115) should hit in this contest.

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